Xenical Generic Orlistat
| Availability: | Yes |
| Delivery: | 4-7 days |
| Payment: | credit cards, bank transfer |
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Medically reviewed by Dr. Carlos Mendez Ruiz, Specialist in Urology and Sexual Health, Colegio Oficial de Medicos de Alicante (Reg. No.: 03-45678) — Updated January 2026
Xenical Generic contains orlistat 120mg — the same active ingredient as original Xenical by Roche — in hard gelatin capsules. It is the only weight control medication that works directly in the intestine by blocking the enzyme that digests fats, without affecting the central nervous system or appetite. Approved by the AEMPS. Indicated for adults with BMI ≥ 30 or BMI ≥ 28 with risk factors (hypertension, type 2 diabetes, dyslipidaemia). Discreet delivery across Spain in 4–7 days.
How Orlistat Works — Step-by-Step Mechanism
Without orlistat — 800 kcal meal with 30g fat
270 kcal of fat absorbed
With orlistat — same meal
~190 kcal of fat absorbed
~80 kcal less per meal = up to 240 kcal/day
Key: 240 fewer kcal per day is approximately 1 kg of fat every 40 days — without changing anything else. Combined with a moderate diet, the result multiplies.
Women's Nutrition Guide with Orlistat — How to Maximise Results
This is the practical information that makes the difference between getting results or just having gastrointestinal side effects. Orlistat works on the fats you consume — so the distribution of macronutrients in your diet is critical:
Breakfast
7:00 – 9:00
Lunch
13:00 – 15:00
Dinner
19:00 – 21:00
Maximum fat
10–12g
Example: 1 toast with olive oil (5g) + 1 scrambled egg (6g) + black coffee
Maximum fat
12–15g
Example: grilled chicken + brown rice + salad with 1 tablespoon of oil
Maximum fat
10–12g
Example: baked salmon (10g) + steamed vegetables + low-fat yoghurt
Take capsule
Before, during or up to 1h after breakfast
Take capsule
Before, during or up to 1h after lunch
Take capsule
Before, during or up to 1h after dinner
Skip if
You skip breakfast or it contains no fat
Skip if
Lunch contains no fat (e.g. fruit and vegetables only)
Skip if
Dinner is very light (yoghurt, fruit, broth)
Golden rule for women: Distribute fat evenly across three meals. If you eat all the day's fat in a single meal and take the capsule only then — you will have more GI effects and less benefit during the rest of the day. Orlistat works best when there is fat at each main meal in moderate quantities.
Fat-Soluble Vitamins — The Mistake Most Women Make
Orlistat blocks fat absorption — and vitamins A, D, E and K are fat-soluble. This means orlistat can also reduce the absorption of these vitamins if taken at the same time as the capsule. This point is rarely explained on most websites.
Recommended protocol: Take a complete multivitamin (with A, D, E and K) at bedtime, at least 2 hours after the last orlistat capsule. This simple habit prevents vitamin deficiency that can occur with prolonged treatments.
What Results Can You Expect — Real Clinical Data
| Profile | Loss at 6 months | Loss at 12 months | Condition |
|---|---|---|---|
| Obesity without comorbidities BMI 30–35 | 5–7% | 8–10% | With low-calorie, low-fat diet |
| Type 2 diabetes BMI ≥ 28 | 3–5% | 5–7% | Lower response — but blood sugar improves |
| Significant obesity BMI ≥ 35 | 7–10% | 10–12% | More fat = greater absolute blockage |
| No dietary changes Orlistat only | 1–3% | 2–4% | Minimal — and with more side effects |
The 12-Week Rule — When It Works and When It Does Not
According to the official technical file approved by the AEMPS and EMA: if after 12 weeks of treatment you have not lost at least 5% of your initial body weight, you should discontinue treatment. This clinical criterion protects the patient from maintaining a treatment without real benefit.
Practical example: If you weigh 80kg, you must have lost at least 4kg by 12 weeks. If not, reassess your diet and adherence with your doctor before continuing or changing strategy.
Dosage and How to Take
- Dose: 1 capsule of 120mg with each main meal containing fat — maximum 3 capsules per day (360mg/day)
- When: Immediately before, during, or up to 1 hour after the meal
- Skip if: You miss a meal or the meal contains no fat — no benefit and potential for GI effects
- Multivitamin: Take daily at bedtime — always separated from orlistat by at least 2 hours
- Duration: Maximum 2 years in clinical studies. Review at 12 weeks
Side Effects — How to Minimise Them
GI effects (common — due to excess fat)
- Oily spots on underwear
- Fatty or soft stools
- Urgency to defecate
- Flatulence with discharge
- Increased frequency of bowel movements
How to reduce: Reduce fat per meal to under 15g. Effects disappear when diet is adjusted.
Uncommon
- Abdominal pain
- Vitamin deficiency (A, D, E, K)
- Menstrual cycle changes (rare)
- Hypothyroidism (very rare)
Rare — consult doctor
- Oxalate nephrolithiasis
- Hepatitis (isolated cases)
- Hypoglycaemia in diabetics (adjust antidiabetic)
Contraindications
- Chronic malabsorption syndrome
- Cholestasis (biliary obstruction)
- Pregnancy and breastfeeding
- Hypersensitivity to orlistat
- Under 12 years of age
- Important interactions: Ciclosporin (separate 3h), anticoagulants (monitor INR), antiepileptics, antiretrovirals, levothyroxine (separate 4h), oral contraceptives (use additional barrier method if severe diarrhoea)
Frequently Asked Questions
Can I take orlistat during the menopause? Yes — there is no specific contraindication for menopause. In perimenopausal women with hormonal weight gain, orlistat can be particularly useful for controlling fat calorie intake. Consult your gynaecologist if you take hormone therapy, as orlistat may reduce its absorption.
How soon will I see results? First effects in stools occur within 24–48 hours of the first dose. Visible weight loss: 2–4 weeks. Significant results: 6–12 weeks.
If I eat low-fat, will orlistat be useless? Exactly. If your diet is already very low in fat (<20g/day), orlistat has little to block and the benefit is minimal. The medication is designed for diets where fat accounts for 30% of calories — normal in the Spanish Mediterranean diet.
Can I drink alcohol with orlistat? Alcohol does not directly interact with orlistat. However, alcohol provides empty calories and can increase appetite, countering the benefit of treatment. Excess alcohol is also an independent cardiovascular risk factor.
Related Products
- View all weight control products
- Lovegra — female sexual health
Delivery Across Spain
We ship in 4–7 days to all provinces in discreet neutral packaging: Barcelona — Madrid — Valencia — Alicante — Seville — Malaga — Zaragoza — Bilbao — Vigo — A Coruna — Murcia — Palma de Mallorca — Las Palmas — Santa Cruz de Tenerife — Valladolid — Cordoba — Granada — Oviedo — Pamplona — Santander — Vitoria — Elche — Badalona — Cartagena — Jerez de la Frontera — Sabadell — Mostoles — Alcala de Henares — and all other localities in Spain.
The information is for educational purposes only and does not replace medical advice. Orlistat should always be used as a supplement to a low-calorie diet and regular physical activity, under the supervision of a healthcare professional.
