Cialis Professional (Tadalafil)
| Availability: | Yes |
| Delivery: | 4-7 days |
| Payment: | credit cards, bank transfer |
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Medically reviewed by Dr. Carlos Méndez Ruiz, Urologist, Registration No. 03-45678, Official College of Physicians of Alicante — Updated January 2026.
Cialis Professional contains the same active ingredient as standard generic Cialis — tadalafil — but in a different pharmaceutical formulation that significantly changes its absorption profile. If you have wondered what actually justifies the "Professional" label, this page answers with precise clinical data: how much faster it acts, why, what that means for practical use, and when it makes sense to choose it over the standard version. From €4.59 per pill — with discreet delivery in 4-7 days across Spain.
What Is Cialis Professional and How Does It Differ from Standard Tadalafil?
The difference between Cialis Professional and a conventional tadalafil tablet is not in the active ingredient — in both it is exactly the same tadalafil at the same dose. The difference lies in the formulation and route of absorption.
The key to the sublingual formulation: the tablet is left to dissolve under the tongue instead of being swallowed. The sublingual mucosa has a dense vascular network that allows direct absorption of tadalafil into the bloodstream, bypassing hepatic first-pass metabolism and shortening the time to effective plasma concentration. The clinical result is an onset of action approximately twice as fast as the standard formulation.
This matters particularly for men who value spontaneity — with Cialis Professional, the planning window shrinks from 30-60 minutes to 15-20 minutes.
How Tadalafil Works — The Mechanism Behind PDE5 Inhibition
All PDE5 inhibitors — including tadalafil in any formulation — work through the same precise physiological mechanism. Understanding it eliminates one of the most common misconceptions about these medications.
Erection requires sexual stimulation. That stimulation triggers the release of nitric oxide (NO) at nerve terminals in the corpus cavernosum of the penis. NO activates guanylate cyclase, which converts GTP to cyclic GMP (cGMP). Elevated cGMP relaxes smooth muscle in cavernosal arteries, allowing increased blood inflow and producing erection. PDE5 is the enzyme that degrades cGMP, ending the erection.
What tadalafil does — and what it does NOT do: Tadalafil blocks PDE5, preserving the elevated cGMP produced by sexual arousal. Without sexual stimulation, there is no NO release, no cGMP elevation, and no erectile effect — regardless of how much tadalafil has been taken. The medication is an amplifier of the normal erectile response, not an autonomous initiator. A man who takes Cialis Professional and waits for "something to happen" without sexual stimulation will notice no effect whatsoever.
Cialis Professional Dosage — Complete Guide
20mg Dose — Standard Use
The recommended starting dose of Cialis Professional is 20mg, taken 15 to 20 minutes before sexual activity. The tablet is placed under the tongue and left to dissolve — it should not be swallowed whole with water. The maximum dose is 1 tablet per day, regardless of the dose used.
40mg Dose — When to Consider the Higher Dose
The 40mg dose is available for men in whom the response to 20mg is insufficient after at least 4-6 correctly performed attempts at the standard dose. Before increasing, it is important to confirm that previous attempts met the correct conditions: sexual stimulation present, no excessive alcohol consumption, no concomitant CYP3A4 inhibitors.
The 4-6 attempts rule: Spanish and European urology guidelines (AEU, EAU) recommend at least 4-6 attempts with correct technique before concluding that a medication is ineffective. Most "failures" on the first attempt are correctable (insufficient stimulation, alcohol, incorrect timing) and do not indicate genuine pharmacological failure.
Can Cialis Professional Be Taken Every Day?
Cialis Professional at 20mg or 40mg is designed for on-demand use — not for continuous daily administration. For men who prefer not to plan the moment, the appropriate alternative is generic tadalafil 5mg in daily dose, which produces continuous steady-state coverage with a generally more favourable side effect profile than high intermittent doses.
Contraindications and Safety Warnings
ABSOLUTE CONTRAINDICATIONS — Do not take
- Nitrates in any form — nitroglycerin (GTN spray, patches), isosorbide dinitrate, isosorbide mononitrate, "poppers" (amyl nitrite). Risk of severe, potentially fatal hypotension. The mandatory safety window with tadalafil is 48 hours — double that of sildenafil (24h)
- Guanylate cyclase stimulators — riociguat (Adempas); absolute contraindication with all PDE5 inhibitors
- Known hypersensitivity to tadalafil or any excipient
- Severe hepatic impairment (Child-Pugh C)
- Under 18 years of age
CAUTION — Consult your doctor
- Antihypertensives — tadalafil potentiates blood pressure-lowering effects
- Uncontrolled hypertension (BP >170/100 mmHg)
- Hypotension (BP <90/50 mmHg)
- Recent cardiac ischaemia (heart attack within 90 days)
- Severe cardiac arrhythmias
- Severe renal impairment (CrCl <30 mL/min) — do not exceed 10mg every 48h
- Retinitis pigmentosa
- Previous priapism (sickle cell anaemia, leukaemia, multiple myeloma)
Drug Interactions — Essential Information
| Drug / Substance | Interaction type | Action required |
|---|---|---|
| Nitrates (GTN, isosorbide, poppers) | ABSOLUTE CONTRAINDICATION | Never combine. Wait 48h after tadalafil before using nitrates |
| Riociguat (Adempas) | ABSOLUTE CONTRAINDICATION | Never combine with any PDE5 inhibitor |
| Ketoconazole, itraconazole, ritonavir, clarithromycin (strong CYP3A4 inhibitors) | Increase tadalafil levels | Do not exceed 10mg/72h with ketoconazole. Reduce dose |
| Rifampicin, carbamazepine, phenytoin, St. John's Wort (CYP3A4 inducers) | Reduce tadalafil levels | Reduced efficacy; dose adjustment may be required |
| Alpha-blockers (tamsulosin, doxazosin) | Additive hypotension | Stabilise alpha-blocker first. Tamsulosin 0.4mg requires no adjustment; other alpha-blockers with caution |
| Alcohol (>3 units) | Hypotension + CNS depression | Limit to maximum 2 standard units; alcohol also independently inhibits erectile function |
Side Effects — Frequency Comparison
Common — 1 to 10% of users
- Headache — the most common; generally mild and self-limiting
- Dyspepsia — mild gastric discomfort
- Facial flushing — cutaneous vasodilation
- Back pain and myalgia — specific to tadalafil due to PDE11 cross-inhibition; appears 12-24h after the dose
- Nasal congestion
- Dizziness — especially with concomitant antihypertensives
Rare but important — seek immediate attention
- Priapism — painful erection lasting more than 4 hours; urological emergency. Go to A&E immediately
- NAION — non-arteritic anterior ischaemic optic neuropathy; sudden vision loss; stop the medication immediately
- Sudden hearing loss — unilateral or bilateral; stop and consult ENT
- Severe hypotension — combined with nitrates; cardiovascular emergency
Who Should Choose Cialis Professional vs Standard Tadalafil?
Both Cialis Professional and standard generic tadalafil contain the same active ingredient and produce the same therapeutic effect. The choice depends on practical preferences and individual needs:
Better choice: Cialis Professional if...
- You value faster onset (15-20 min vs 30-60 min for standard)
- You prefer not needing water to take the medication
- Your response to standard tadalafil 20mg has been good but you want faster action
- You need the 40mg dose not available in standard generic tadalafil
- You have difficulty swallowing tablets
Better choice: Standard generic tadalafil if...
- Price is the main factor — up to 70% cheaper
- You don't mind planning 30-60 minutes ahead
- You prefer daily low-dose 5mg for continuous coverage
- It's your first time with tadalafil — better to start with standard dose and assess response
- You use the medication regularly and the cumulative saving is significant
Complete PDE5 Inhibitor Comparison — Choose With Knowledge
| Parameter | Cialis Professional Sublingual tadalafil |
Generic Tadalafil Standard tablet |
Generic Sildenafil Viagra generic |
Vardenafil Levitra generic |
|---|---|---|---|---|
| Onset of action | 15–20 min | ~2 hours | 45–60 min | 30–60 min |
| Duration of effect | Up to 36h | Up to 36h | 4–6h | 4–5h |
| Fatty meal effect | No effect | No effect | Cmax ↓29% | Cmax ↓18% |
| Nitrate window | 48h | 48h | 24h | 24h |
| Daily dose available | No | Yes (5mg) | No | No |
| PDE5 potency (Ki) | 0.94 nM | 0.94 nM | 3.9 nM | 0.7 nM (highest) |
| Price from (cialiscomprar.com) | €4.59/pill | €1.10/pill | €1.39/pill | €1.80/pill |
Cialis Professional Prices — From cialiscomprar.com
All prices include delivery across Spain in 4-7 business days with completely discreet packaging and no reference to the contents.
| Dose | Quantity | Total price | Price per pill |
|---|---|---|---|
| 20mg | 10 pills | €45.99 | €4.60 |
| 20mg | 30 pills | €99.59 | €3.32 |
| 20mg | 90 + 2 free | €229.99 | €2.55 — best value |
| 40mg | 10 pills | €61.99 | €6.20 |
| 40mg | 90 + 2 free | €331.99 | €3.69 — best value |
Delivery Across Spain
We deliver Cialis Professional in 4-7 business days to all Spanish provinces. All orders are sent in plain unmarked packaging with no reference to the medication or sender.
Madrid (Madrid, Alcalá de Henares, Móstoles, Alcorcón, Getafe) — Barcelona (Barcelona, Hospitalet, Badalona, Terrassa, Sabadell) — Valencia (Valencia, Alicante, Elche, Torrevieja, Benidorm) — Seville (Seville, Dos Hermanas, Jerez, Cádiz, Málaga) — Zaragoza — Bilbao (Bilbao, Vitoria, San Sebastián) — Málaga — Murcia — Palma de Mallorca — Canary Islands (Las Palmas, Santa Cruz de Tenerife) — and all other cities and municipalities across Spain.
Frequently Asked Questions — Cialis Professional in Spain
How is Cialis Professional different from regular generic Cialis? The difference is not in the active ingredient — in both it is tadalafil at the same dose — but in the formulation. Cialis Professional uses sublingual technology that accelerates absorption directly through the oral mucosa, reducing onset from 30-60 minutes (standard swallowed tablet) to 15-20 minutes. Duration of effect — up to 36 hours — is equivalent in both formulations.
How long before sex should I take it? 15 to 20 minutes before sexual activity. The tablet must dissolve under the tongue, not be swallowed with water. Fasting is not required — unlike sildenafil, tadalafil absorption is not clinically affected by food.
How long does the effect last? Up to 36 hours. This means the enhanced erectile response to sexual stimulation is available throughout that window — not a continuous 36-hour erection. Once the sexual encounter ends and stimulation stops, the erection resolves normally.
Can I take Cialis Professional if I have high blood pressure? It depends on the antihypertensive medication you use. Tadalafil potentiates the blood pressure-lowering effect of most antihypertensives — monitor your blood pressure. It is absolutely prohibited to combine with nitrates (GTN spray, isosorbide, "poppers"). If you use alpha-blockers such as tamsulosin for prostate, the combination is generally safe with caution. Consult your doctor.
How long must I wait between Cialis Professional and nitrates? 48 hours — double that of sildenafil or vardenafil, due to tadalafil's prolonged half-life (17.5 hours). This window applies in both directions: both after taking tadalafil and before taking it if you use nitrates.
Why do I get back pain after taking tadalafil? Back and muscle pain is a side effect specific to tadalafil — not shared by sildenafil or vardenafil — due to cross-inhibition of PDE11, an enzyme present in muscle tissue. It typically appears 12-24 hours after the dose and resolves within 48 hours without treatment. Generally mild; if severe, consult your doctor.
How long does delivery to Spain take? Standard delivery takes 4 to 7 business days for mainland Spain. Balearic and Canary Islands may require 1-2 additional days. All orders include a tracking number and arrive in plain unmarked packaging.
Other Erectile Dysfunction Products at cialiscomprar.com
- Generic Tadalafil (Generic Cialis) — from €1.10/pill; same molecule at a lower price
- Cialis Original (Eli Lilly) — original brand; 5mg daily available
- Cialis Super Active — soft gel capsule; even faster dissolution
- Cialis Soft Tabs — chewable tadalafil tablet
- Viagra Professional — sublingual sildenafil; onset 20-30 min
- Apcalis SX Oral Jelly (Tadalafil) — tadalafil in oral jelly format; onset 15-20 min
This page is informational and does not replace medical consultation. Tadalafil is a prescription medication in Spain. The most important contraindications are nitrates (mandatory 48-hour window) and riociguat. In case of erection lasting more than 4 hours, go to A&E immediately. Reviewed by Dr. Carlos Méndez Ruiz, Urologist, Registration No. 03-45678 — January 2026.
