Generic Cialis (Tadalafil)
| Availability: | Yes |
| Delivery: | 4-7 days |
| Payment: | credit cards, bank transfer |
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Medically reviewed by Dr. Carlos Méndez Ruiz, Specialist in Urology and Sexual Health, Colegio Oficial de Médicos de Alicante (Reg. No.: 03-45678) — Updated January 2026
Generic Cialis contains tadalafil — the same active ingredient as original Eli Lilly Cialis, whose patent expired in Spain in November 2017. Since then, generic tadalafil has been available at prices up to 85% lower with identical clinical efficacy. It is the only PDE5 inhibitor with an effect of up to 36 hours — hence its nickname «the weekend pill»: a dose taken on Friday night is still active on Sunday morning. It is also the only PDE5 approved for daily therapy and for the treatment of benign prostatic hyperplasia (BPH). Available in 5mg, 10mg, 20mg and 40mg. Discreet delivery across Spain in 4–7 days.
Why Does Tadalafil Last 36 Hours? — The Pharmacokinetics That Explain Everything
The exceptional duration of tadalafil has a clear scientific basis. Its elimination half-life is ~17.5 hours — more than double that of sildenafil (~4h) or vardenafil (~4–5h). This means the drug remains at therapeutic concentrations in the blood for over a day and a half after a single 20mg dose.
Additionally, tadalafil is not affected by food — unlike sildenafil, whose absorption is delayed by up to 30% with fatty meals. With tadalafil, you can eat normally and take the tablet before or after dinner without losing efficacy.
Key clinical data
In controlled studies with over 700 patients, 88% of men with erectile dysfunction reported significant improvement with tadalafil. This is one of the strongest efficacy data points among all PDE5 inhibitors.
The 4 Tadalafil Doses — Which One Is Right for You?
| Dose | For whom | How to take | Indication |
|---|---|---|---|
| 5mg | Frequent sexual activity (≥2x/week), ED + BPH simultaneously, those wanting total spontaneity | 1 tablet every day at the same time, regardless of sexual activity | Daily therapy — only approved PDE5 |
| 10mg | First time with tadalafil, men over 65, mild-moderate dysfunction | 30–60 min before sexual activity, max. 1x/24h | Recommended starting dose per EMA guidelines |
| 20mg | Men who don't respond adequately to 10mg, moderate-severe dysfunction | 30–60 min before, max. 1x/24h. With or without food | Most widely used standard on-demand dose |
| 40mg | Resistant cases not responding to 20mg | Medical supervision only, max. 1x/24h | Off-label — higher risk of side effects |
Daily Therapy with Tadalafil 5mg — Total Spontaneity
Daily therapy is the most chosen option for men with an active sex life. By taking 5mg every day, steady plasma concentrations of tadalafil are maintained without peaks or troughs — the effect is always present when sexual arousal occurs:
- No planning: Nothing needs to be taken before sex. Erection can occur at any time with stimulation, just as without medication
- Dual indication: Daily tadalafil 5mg is simultaneously approved for ED and for reducing urinary symptoms of BPH — urgency, nocturia, weak flow
- Recommended if: You have sex at least twice a week, you also have BPH, or you prefer not to «prepare» for intimacy
- Steady-state onset: Stable concentrations are reached after 5 days of daily dosing
Tadalafil vs Sildenafil — When to Choose Each?
| Parameter | Tadalafil — Generic Cialis | Sildenafil — Generic Viagra/Kamagra |
|---|---|---|
| Duration of action | Up to 36 hours | 4–6 hours |
| Food influence | None | Significant — take on empty stomach |
| Daily therapy | Yes (5mg/day) — approved | Not approved |
| BPH treatment (prostate) | Yes — unique in class | No |
| Blue-tinted vision | Rare | Possible (PDE6) |
| Choose tadalafil if... | You value spontaneity, have BPH, prefer not to plan the dose, or use it more than 2x/week | You plan intercourse in advance, want the lowest price, or it's your first try |
Back Pain — The Side Effect Unique to Tadalafil
One side effect that distinguishes tadalafil from all other PDE5 inhibitors is lower back or muscle pain. It occurs in ~5% of users, typically 12–24 hours after taking the dose, and resolves on its own within 48 hours.
Why it happens: Unlike sildenafil, tadalafil has some activity on PDE11 — an enzyme present in skeletal muscle and spinal tissue. This mild inhibition can produce muscle discomfort that is harmless but noticeable.
What to do: If it occurs, take a mild analgesic (paracetamol) and wait — it disappears on its own. If intense or persisting beyond 48h, consult your doctor. With daily 5mg therapy, this effect is very infrequent.
Side Effects
Common (1–10%)
- Headache
- Dyspepsia (indigestion)
- Back or muscle pain
- Facial flushing
- Nasal congestion
- Mild dizziness
Uncommon — contact doctor
- Hypotension
- Blurred vision
- Rapid heartbeat
- Limb swelling
Rare — A&E immediately
- Priapism (erection >4h)
- Sudden vision loss
- Sudden hearing loss
Absolute Contraindications
- Nitrates (nitroglycerin spray, isosorbide dinitrate or mononitrate) — severe potentially fatal hypotension
- Poppers (amyl or butyl nitrite)
- Riociguat (Adempas)
- Heart attack or stroke in the last 3–6 months
- Unstable angina or severe heart failure (NYHA IV)
- Severe hypotension (<90/50 mmHg)
- Severe hepatic impairment (Child-Pugh C)
- Under 18 years of age | Women
Key Interactions
- Alpha-blockers (tamsulosin, doxazosin — common in BPH): additive hypotension risk. In combined ED + BPH therapy — separate doses by at least 4 hours. Tamsulosin 0.4mg has the lowest risk among alpha-blockers
- CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin): increase tadalafil levels — reduce maximum dose to 10mg every 72h
- CYP3A4 inducers (rifampicin, carbamazepine, St John's Wort): reduce tadalafil efficacy
- Alcohol: Moderate (≤2 drinks) tolerated. Large amounts potentiate hypotension and may impair erection
Frequently Asked Questions
Can I take Generic Cialis after a large dinner? Yes — unlike sildenafil, tadalafil can be taken with or without food at any time of day without loss of efficacy. This is one of its greatest practical advantages.
When does Generic Cialis start working? The effect begins 30 minutes after taking. Peak plasma concentration is reached at 2 hours. The ability to achieve an erection with sexual stimulation is maintained for up to 36 hours. Some men notice an effect as early as 16 minutes.
Tadalafil 5mg daily or 20mg on-demand? If you have sex twice or more per week — daily therapy with 5mg is usually more convenient and may be more economical overall. If sex is less frequent and planned — 20mg on-demand is sufficient.
I have prostate enlargement and erectile dysfunction — is there one medication for both? Yes — daily tadalafil 5mg is the only medication approved to simultaneously treat ED and urinary symptoms of BPH. It is particularly valued by urologists for men over 50 with both conditions.
Related Products
- Cialis Brand (Eli Lilly) — original brand Cialis
- Cialis Professional — sublingual formulation, faster onset
- Cialis Soft Tabs — chewable tablets
- Cialis Super Active — gel capsules, fast absorption
- Apcalis SX Oral Jelly — tadalafil oral gel, onset 15–20 min
- Generic Viagra — sildenafil, more economical alternative for on-demand use
Delivery Across Spain
We ship in 4–7 days to all provinces in discreet neutral packaging: Barcelona — Madrid — Valencia — Alicante — Seville — Málaga — Zaragoza — Bilbao — Vigo — A Coruña — Murcia — Palma de Mallorca — Las Palmas — Santa Cruz de Tenerife — Valladolid — Córdoba — Granada — Oviedo — Pamplona — Santander — Vitoria — Elche — Badalona — Cartagena — Jerez de la Frontera — Sabadell — Móstoles — Alcalá de Henares — and all other localities in Spain.
The information is for educational purposes only and does not replace medical advice. Before taking tadalafil, consult your doctor, especially if you take nitrates, alpha-blockers or other cardiovascular medications.
