Generic Priligy Dapoxetine
| Availability: | Yes |
| Delivery: | 4-7 days |
| Payment: | credit cards, bank transfer |
 |
Medically reviewed by Dr. Carlos Méndez Ruiz, Urologist, Registration No. 03-45678, Official College of Physicians of Alicante — Updated January 2026.
Dapoxetine is a short-acting, ultra-rapid selective serotonin reuptake inhibitor (SSRI) developed specifically for on-demand treatment of premature ejaculation (PE). It is the only active ingredient approved by the EMA for this indication. Unlike conventional antidepressant SSRIs — which require weeks of daily use to produce an effect — dapoxetine is designed to be taken 1-3 hours before sexual intercourse and is eliminated almost completely within 24 hours, without accumulation. From €3.87 per pill with discreet delivery in 4-7 days across Spain.
Important: dapoxetine ≠ PDE5 inhibitors: Dapoxetine does not treat erectile dysfunction (ED) — these are different conditions with distinct mechanisms. Premature ejaculation is a problem of ejaculatory reflex control; erectile dysfunction is a problem of cavernosal blood flow. If you have both conditions simultaneously, the combined product Super P-Force (sildenafil + dapoxetine in one tablet) may be appropriate. For ED alone, the correct products are PDE5 inhibitors: tadalafil or sildenafil.
Premature Ejaculation — Clinical Context
Premature ejaculation (PE) affects approximately 20-30% of men at some point in their lives, making it the most common male sexual disorder. The current clinical definition (International Society for Sexual Medicine, ISSM) requires three criteria: intravaginal ejaculation latency time (IELT) of less than 1 minute in most penetrations, inability to voluntarily delay ejaculation, and negative personal or relational consequences.
The standard objective measure is the IELT — the time elapsed between penetration and ejaculation. In men with PE, the median IELT is approximately 0.9-1 minute. In men without PE, the median IELT is approximately 5-6 minutes. The goal of treatment is not to reach any arbitrary number, but to reduce distress and increase perceived control.
How Dapoxetine Works — Why It Acts On-Demand When Classic SSRIs Require Weeks
Ejaculatory reflex control is modulated by spinal and supraspinal serotonergic pathways. Serotonin (5-HT) exerts an inhibitory effect on the ejaculatory reflex via 5-HT2c receptors: higher synaptic serotonin translates to longer ejaculatory latency. In men with PE, there is evidence of serotonergic hypoactivity in these pathways.
Clinical Efficacy — What to Realistically Expect
×3
Average IELT increase with dapoxetine 60mg
From ~1 min to ~3 min on average
~90%
Men reporting improved control
Measured by PEP scale
30mg
Recommended starting dose
Escalate to 60mg only if needed
Managing expectations is important. Dapoxetine does not cure premature ejaculation — it provides pharmacological control during the period of effect. In most men, IELT returns to baseline when the medication is stopped. This distinguishes it from psychotherapeutic or behavioural approaches (stop-start technique, squeeze technique) which can produce more lasting improvements, though with slower implementation. Optimal treatment in many cases combines dapoxetine short-term with behavioural techniques.
Dosage — How to Take Dapoxetine Correctly
Dapoxetine 30mg — Starting dose
- Recommended initial dose for all new users
- Allows tolerability assessment before escalating
- Clinically significant efficacy in ~60% of men
- Better side effect profile (lower nausea and dizziness rates)
- If response insufficient after 2-3 attempts: escalate to 60mg
Dapoxetine 60mg — Full dose
- For men with insufficient response to 30mg
- Greater efficacy (IELT ~3x vs ~2x with 30mg)
- Higher incidence of nausea (11-22%), dizziness and headache
- Higher syncope risk — postural precautions required
- Maximum approved dose — do not exceed
Administration instructions — the details that make a difference
- Take 1-3 hours before planned sexual activity — Tmax is 1-2 hours; taking too close to intercourse reduces efficacy
- With a large glass of water — adequate hydration reduces vasovagal syncope risk
- With or without food — food slightly delays Tmax but does not reduce efficacy; fasted onset is faster
- Remain seated or lying down for 30 minutes after taking — vasovagal syncope risk is highest in the first hour; rise slowly and carefully
- Avoid alcohol on the day of taking — potentiates sedative effects and syncope risk
- Maximum 1 tablet per day — dapoxetine is designed for on-demand use, not continuous
Vasovagal syncope — the least-known side effect: Dapoxetine can cause vasovagal syncope (fainting) in approximately 0.06% of users (6/10,000), especially in the first hour after taking and in situations of dehydration, heat or prolonged standing. Warning signs include dizziness, nausea and feeling hot. Sit or lie down immediately if these appear. This precaution is especially important on the first dose and when taking 60mg.
Contraindications — Especially Critical for Dapoxetine
ABSOLUTE CONTRAINDICATIONS — Risk of Potentially Fatal Serotonin Syndrome
- MAOIs — monoamine oxidase inhibitors (phenelzine, tranylcypromine, selegiline, moclobemide): risk of severe or fatal serotonin syndrome. Do not take dapoxetine within 14 days of stopping a MAOI; do not start a MAOI until 7 days after dapoxetine
- Thioridazine — serotonin syndrome risk
- Linezolid — antibiotic with MAOI properties
- Lithium — serotonergic potentiation
- Other SSRIs or SNRIs (fluoxetine, sertraline, paroxetine, venlafaxine, duloxetine) — do not combine; serotonin syndrome and SSRI overdose risk
- Tramadol — SSRI activity + opioid; serotonin syndrome risk
- Migraine triptans (sumatriptan, rizatriptan)
- Moderate-severe hepatic impairment (Child-Pugh B-C)
- Under 18 years of age
CAUTION — Consult your doctor
- Strong CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin) — significantly increase dapoxetine levels; do not exceed 30mg with these medications
- CYP2D6 inhibitors (fluoxetine, paroxetine, quinidine)
- Hypovolaemia, dehydration — higher syncope risk
- History of vasovagal syncope
- Bipolar disorder or schizophrenia — risk of manic episode
- Narrow-angle glaucoma
Side Effects
| Side effect | Dapoxetine 30mg | Dapoxetine 60mg | Note |
|---|---|---|---|
| Nausea | ~11% | ~22% | Most common; taking with food reduces incidence |
| Headache | ~6% | ~9% | Generally mild and self-limiting |
| Dizziness | ~7% | ~15% | Stay seated for the first hour |
| Diarrhoea | ~3% | ~4% | Generally mild |
| Insomnia | ~2% | ~3% | SSRI stimulant effect |
| Vasovagal syncope | Rare (<0.1%) | Rare (<0.1%) | Stay seated 30 min after taking |
| Serotonin syndrome | Only if CI | Only if CI | Medical emergency — never combine with MAOIs/SSRIs |
Prices — cialiscomprar.com
| Quantity (60mg) | Total price | Price per pill |
|---|---|---|
| 10 pills | €45.36 | €4.54 |
| 20 + 4 free | €73.63 | €3.06 |
| 30 + 6 free | €101.57 | €2.82 |
| 90 + 10 free | €252.99 | €2.53 — best value |
| 180 + 10 free | €471.20 | €2.48 — lowest price |
All prices include discreet delivery across Spain in 4-7 business days, unmarked packaging, and a tracking number with every order.
Frequently Asked Questions
Does dapoxetine also treat erectile dysfunction? No. Dapoxetine is an SSRI specifically designed for premature ejaculation — it acts on the ejaculatory reflex by modulating serotonergic pathways. Erectile dysfunction is a different condition (failure of the vascular erection mechanism) requiring a PDE5 inhibitor (sildenafil, tadalafil, vardenafil). If you have both conditions simultaneously, Super P-Force combines sildenafil + dapoxetine in one tablet.
Why does dapoxetine work from the first dose when antidepressant SSRIs take weeks? Because of its unique pharmacokinetics: Tmax of 1-2 hours and elimination half-life of ~1.5 hours. This ultra-rapid absorption and elimination means plasma concentration rises and falls quickly enough to allow on-demand use. Antidepressant SSRIs have half-lives of 15-90 hours and require weeks to reach steady state.
How much does dapoxetine actually improve IELT? Clinical trials show a mean increase of ~3× baseline IELT with the 60mg dose (from ~1 minute to ~3 minutes on average). Some men experience greater improvements; others less. The clinical success criterion is not a fixed number but reduction in distress and increase in perceived control, which ~90% of participants report with dapoxetine.
Can I combine dapoxetine with Cialis or Viagra? Yes, with precautions. Dapoxetine + sildenafil or tadalafil have no direct pharmacokinetic interaction. The combination may slightly increase hypotension and dizziness risk. The most practical option for those needing both effects is Super P-Force (sildenafil 100mg + dapoxetine 60mg). Do not combine dapoxetine with PDE5 inhibitors AND nitrates simultaneously.
What is serotonin syndrome and why is the warning so important? Serotonin syndrome is a medical emergency caused by excess synaptic serotonin, occurring when two or more serotonergic agents are combined. Symptoms include: agitation, confusion, diaphoresis, tremors, hyperreflexia, high fever and, in severe cases, seizures and death. Combining dapoxetine + MAOIs is absolutely prohibited — the safety gap is 14 days between MAOI and dapoxetine. Combination with other SSRIs is also contraindicated.
Can dapoxetine cause dependence? No. Unlike conventional antidepressant SSRIs that require gradual tapering when stopped, dapoxetine is designed for on-demand use and its ultra-rapid elimination avoids discontinuation syndrome. It can be taken or stopped without a gradual tapering schedule.
Related Products at cialiscomprar.com
- Super P-Force (Sildenafil 100mg + Dapoxetine 60mg) — combined solution for men with simultaneous PE + ED
- Generic Sildenafil (Generic Viagra) — PDE5 inhibitor only, for ED without PE
- Generic Tadalafil (Generic Cialis) — 36h PDE5 inhibitor, for ED without PE
- Kamagra 100mg — generic sildenafil from Ajanta Pharma
This page is informational and does not replace medical or psychological consultation. Premature ejaculation may have significant psychological components — consider combining sexual therapy with pharmacological treatment. Dapoxetine is contraindicated with MAOIs and other SSRIs — risk of potentially fatal serotonin syndrome. In case of syncope after taking, go to A&E. Reviewed by Dr. Carlos Méndez Ruiz, Urologist, Registration No. 03-45678 — January 2026.
